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G-protein response modifiers for rosacea: 04-26-10
Rosacea cleanser for hyper-sensitive skin: 04-26-10
Rosacea skin serum for thin-red skin: 04-26-10
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G-Protein Response Modifiers for Rosacea Tx.
April 26, 2010 | Dr. Geoffrey Nase | Rosacea Treatment | Rosacea News |
I have been researching G-Protein Response Modifiers for nearly seven years due to their exciting potential for rosacea treatment and have been involved in preliminary G-Protein testing for vascular hyper-responsiveness, uncontrolled vascular growth and vascular repair mechanisms; we have successfully incorporated a G-Protein Response Modifier into our oral treatment Rosadyn™... it's called Sulforaphane, and it activates two key vascular repair enzymes that are capable of reversing rosacea-induced blood vessel damage. G-Protein research and treatment application are two of our primary fields of study as Bio-Medical Research Physiologists. They are also one of the keys to rosacea remission... not a rosacea cure... but certainly capable of inducing remission.
It's widely documented that one treatment or medication can't block dozens of dilator proteins and inflammatory substances produced in rosacea-affected skin AND all of their receptors, but you can block one specific "G-Protein" that is required to activate many of these pro-inflammatory receptors and effectively halt the inflammatory signal. This is called selective receptor blockade. This means that if a dilator substance (a key) binds onto a receptor (a lock), a g-protein must couple the "key" to the "lock" to allow further action. If the g-protein cannot couple these two, then nothing happens.... the cells are never told to dilate AND inflammatory cells are never told to be produced. Plus, DNA is never told to replicate into damaging enzymes, proteins and peptides. This is selective targetting of g-proteins without side effect. You selectively block the g-protein from "coupling" to the lock and key.
There is now a G-Protein response modifier available oversees in Japan that blocks neutrophil-mediated inflammation. They are using it solely for cosmeceuticals and anti-aging but it has excellent potential to reduce rosacea inflammation by blocking neutrophil-mediated damage... rosacea is a neutrophil-based disorder. This company and its CEO are not aware of the potential of this product for rosacea treatment. We can use this product right now, as is, and I would predict that it would be the most effective anti-rosacea topical to date, bar none.
Plus, this Biotech company is now developing treatments specifically for rosacea at the vascular level. This is excellent news and should be available at least one millennium before anything productive comes from the National Rosacea Society;) Block one G-protein to block one dozen rosacea inflammatory pathways. This is what's termed "smart medicine"... comparable to the "smart bomb". Selective, effective and very few side effects.
I am completing an interview with several companies currently researching and developing oral and topical g-protein inhibitors for inflammatory dermatoses and rosacea.... and publishing a Dermatology journal article to send to the Biotech company (Signum Biosciences) to educate them on the potential rosacea market for their current anti-aging treatment.
Signum Biosciences is developing a new product based on G-protein Response Modulation. Their first product, for anti-aging, called Arazine will be available in two to four months and they are currently working on a second generation of products to target inflammatory skin disorders such as rosacea, psoriasis and eczema.
What they don't realize yet is that Arazine is an excellent treatment choice for rosacea due to its anti-inflammatory actions in the skin and its affect on damaging neutrophils. It is more than an anti-aging product. We can use this right now!
According to Signum Bioscience’s Development Pipeline, SIG990 is in the preclinical phase as a rosacea treatment.
G-protein Response Modulators
Signum Bioscience’s patented compounds and methods revolve around a group of derivatives called prenyl peptides. Signum’s GPM Technology Platform constitutes a new class of non-steroidal anti-inflammatories that have broad utility over multiple therapeutic areas by acting as G-protein modulators (GPMs). Initially anti-aging and anti-inflammatory compounds will have immediate impact in skin care products as topical cosmeceuticals (e.g. Arazine™) followed by pharmaceutical inflammatory skin applications. Furthermore, Signum’s goal is the development of anti-inflammatory pharmaceuticals.
GPM Pharmaceutical Development
The most common topical treatment options include antimicrobial agents (e.g. Metrogel, Clindamycin, Clindamycin-Benzoyl peroxide, Sodium Sulfacetamide/Sulfur and Finacea) which inhibit ROS generation by neutrophils, thereby reducing inflammation. However, these treatments do not reduce the initiating inflammatory events (inflammatory mediator release and neutrophil recruitment) of rosacea.
Conversely, GPMs inhibit inflammation directly and indirectly by reducing activity and/or expression of all the key players in rosacea, not just ROS production
Results demonstrate that GPMs
• Inhibit release of key inflammatory mediators (e.g. TNF-α, IL-6, IL-8, VCAM-1, GM-CSF, Gro-α, MCP-1)
• Inhibit neutrophil adhesion and infiltration
• Inhibit ROS production from neutrophils
Given Arazine’s safety and effectiveness as an anti-inflammatory, second generation GPM compounds, provide an effective nonsteroidal alternative for patients suffering from skin diseases such as: rosacea, acne, psoriasis and eczema.
The first GPM based topical containing Arazine is planned to be released to the Japanese market in the second quarter of 2010.
G-Protein Animation
Below is a link to an excellent animation on how G-Proteins work and why they are important treatment targets. If you stop the G-Protein from coupling to the inflammatory protein (ligand) and receptor, then the signal is never received within the cell... in this case it would mean that inflammatory signals would never reach their destination. Play the animation and pay special attention to the G-Protein Subunits in the lower right hand column. If we keep them uncoupled, we block the entire event... safely and without side effect. There will be a quiz;)
G-Protein Animation Series
BTW, I know its not exactly AVATAR but as far as scientific animation goes, its pretty cool. Imagine trying to read that in a medical textbook!
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New Rosacea Cleanser for Hyper-Sensitive Skin
April 26, 2010 | Dr. Geoffrey Nase | Rosacea Treatment | Rosacea Skin Care |
La Roche Posay continues to focus on skin care treatments for rosacea and hyper-sensitive skin. They just released one of the best treatment cleansers to date - "La Roche-Posay Physiological Cleansing Gel". It is nearly as gentle as water, creates a nice gel foam, and removes excess oils from the skin's surface... while depositing key moisturizing ingredients at the same time. As with any topical skin care product,, rosacea sufferers will all respond differently... but this is a great one to experiment with. Thus far the feedback from rosacea sufferers and dermatologists have been excellent. This is a unique product because it is the first one to utilize Poloxamar, one of the gentlest cleansing agents available. It also utilizes two forms of Poloxamar, the first form is to cleanse the outer skin cells (Poloxomar 184) and the second agent is designed to enter the pores for a deeper cleansing (Poloxamar 124). This cleanser also employs three unique skin moisturizers:
"This cleanser was developed for rosacea skin. Gently and completely remove impurities while keeping the skin perfectly pH balanced with La Roche-Posay Physiological Cleansing Gel. This unique soap-free cleansing gel feels soothing on the skin, and rinses off without causing irritation or dryness.
For all skin types, and ideal for those with sensitive skin or dry skin.
Poloxamer is mild soap-free cleansing agent and is considered gentle enough to be used in contact lens solutions. La Roche-Posay Thermal Spring Water is rich in antioxidants and protects the epidermis from damage and dryness."
Ingredient List
Water, PEG 7 Glyceryl Cocoate, Poloxamer 184, Poloxamer 124, Acrylamide (Sodium Acryloyldimethyltaurate Copolymer), Cetearyl Ethylhexanoate, Isohexadecane, Sodium Hydroxide, Ammonium Polyacryldimethyl Tauramide (Ammonium Polyacryloyldimethyl Taurate), Isopropyl Myristate, Polysorbate 80, Caprylyl Glycol, Myrtrimonium Bromide, Benzoic Acid, Fragrance (Parfum)
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New Rosacea Therapy for Thin/Red Skin
April 26, 2010 | Dr. Geoffrey Nase | Rosacea Treatment | Rosacea News |
Once again, La Roche Posay comes through for rosacea. They developed a new skin serum to thicken and repair the epidermis and are currently selling it as an antiaging product; however, it is ideal for rosacea skin. It contains Carnosine which stimulates epidermal growth better than most Epidermal Growth Factors, and Micellized Pycnogenol, which reduces redness and stregnthens blood vessels. It is also an excellent moisturizer for rosacea sensitive skin.
La Roche-Posay Derm AOX is excellent for those with thin, fragile skin OR those with vessels that are extremely superficial.
You can read clinical studies and anecdotal reports about Carnosine and this product on our Rosacea Knowledge Forum.
La Roche-Posay Derm AOX:
Smooth your skin and restore its natural radiance by slowing down the aging process with Derm AOX, an anti-glycation + anti-oxidant serum. Derm AOX contains two active properties to help delay the onset of physical aging in the skin—Carnosine and Pycnogenol. By addressing two of the most damaging reactions in the skin, glycation and oxidation, this innovative formula provides a defense against premature aging that is simply unrivaled.
Anti-glycation skincare is the by-product of diabetes research. In an effort to prevent complications commonly experienced in diabetics, scientists discovered that their newly created compounds had dramatically favorable effects on the skin.
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