Topics Discussed Below
- Introduction
- Clinical Study: Effect of botox on facial blushing & facial
flushing
- Clinical Study: Effect of laser treatment on rosacea symptoms
- Clinical Study: Effect of cyclosporine on severe ocular rosacea
- Clinical Study: Effect of periostat on rosacea papules &
pustules
- Clinical Study: Effect of topical clonidine on rosacea burning
& redness
I. Introduction
Small clinical studies
are always being conducted on inflammatory skin disorders such as
rosacea. Usually physicians and rosacea sufferers do not know
about these studies until after the study is published and becomes
common knowledge. As a general rule of thumb, it takes 6 to
10 months for a study to be completed from its commencement and
another 8 to 12 months for it to be published in a medical journal
-- so rosacea sufferers usually have no idea that studies on the
causes and treatment of rosacea are taking place for over a year
following the actual testing. It is paramount that we learn about
these studies from their commencement and keep track of their progress.
Below is a listing of rosacea studies underway or undergoing the
approval process.
II. Clinical Study: Effect of Botox Treatment on Facial Blushing
and Facial Flushing
A clinical study is underway
in Sydney, Australia to determine the effect of Botox injections
on facial blushing and flushing. This study will determine the overall
effectiveness of Botox treatment and its duration of effect. Preliminary
results will be forwarded to me in Fall 2003 and posted to this
site. This investigator may also evaluate patch iontophoresis of
Botox over large areas of the facial skin and Botox application
following Photoderm treatment .
III. Clinical Study: Effect of Laser Treatment on Rosacea
Symptoms
This clinical laser study
is currently going through the Human Research Committee for approval.
Upon approval, the investigators will evaluate the effect of laser
treatment on rosacea telangiectasia, facial redness, facial blood
flow, facial flushing, vascular density and angiogenesis. Results
will be forwarded to me upon completion of the study and will be
posted to this site.
IV. Clinical Study: Effect of Cyclosporine Treatment on Severe
Ocular Rosacea
This clinical study is
currently going through the Human Research Committee for approval.
Upon approval, the investigators will evaluate the effect of topical
cyclosporine drops on severe ocular rosacea symptoms such as eyelid
and ocular surface inflammatory proteins, tear quality and quantity,
corneal changes, keratitis and keratoconjunctivitis sicca . The
results of the study will be posted to this site upon publication
of the study.
V. Clinical Study: Effect of Periostat on Rosacea Papules
& Pustules
This clinical study is
already underway. This study will determine the effect of oral Periostat
on rosacea papules and pustules. These same investigators are also
interested in determining the effectiveness of Periostat on ocular
rosacea symptoms.
VI. Clinical Study: Effect of Topical Clonidine on Rosacea Burning
Sensations and Facial Redness
This clinical study is currently going through
the Human Research Committee for approval. Upon approval, the investigators
will evaluate the effect of topical clonidine (0.5% - 2.0%) on burning
sensations and chronic facial redness. The results of the study
will be posted to this site upon publication of the study.
