Topics Discussed Below

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• Introduction
  
• Clinical Study: Effect of botox on facial blushing & facial flushing
  
• Clinical Study: Effect of laser treatment on rosacea symptoms
  
• Clinical Study: Effect of cyclosporine on severe ocular rosacea
  
• Clinical Study: Effect of periostat on rosacea papules & pustules
  
• Clinical Study: Effect of topical clonidine on rosacea burning & redness

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I.  Introduction

Small clinical studies are always being conducted on inflammatory skin disorders such as rosacea.  Usually physicians and rosacea sufferers do not know about these studies until after the study is published and becomes common knowledge.  As a general rule of thumb, it takes 6 to 10 months for a study to be completed from its commencement and another 8 to 12 months for it to be published in a medical journal -- so rosacea sufferers usually have no idea that studies on the causes and treatment of rosacea are taking place for over a year following the actual testing. It is paramount that we learn about these studies from their commencement and keep track of their progress. Below is a listing of rosacea studies underway or undergoing the approval process.

II.  Clinical Study: Effect of Botox Treatment on Facial Blushing and Facial Flushing

A clinical study is underway in Sydney, Australia to determine the effect of Botox injections on facial blushing and flushing. This study will determine the overall effectiveness of Botox treatment and its duration of effect. Preliminary results will be forwarded to me in Fall 2003 and posted to this site. This investigator may also evaluate patch iontophoresis of Botox over large areas of the facial skin and Botox application following Photoderm treatment .

III.  Clinical Study: Effect of Laser Treatment on Rosacea Symptoms

This clinical laser study is currently going through the Human Research Committee for approval. Upon approval, the investigators will evaluate the effect of laser treatment on rosacea telangiectasia, facial redness, facial blood flow, facial flushing, vascular density and angiogenesis. Results will be forwarded to me upon completion of the study and will be posted to this site.

IV.  Clinical Study: Effect of Cyclosporine Treatment on Severe Ocular Rosacea

This clinical study is currently going through the Human Research Committee for approval. Upon approval, the investigators will evaluate the effect of topical cyclosporine drops on severe ocular rosacea symptoms such as eyelid and ocular surface inflammatory proteins, tear quality and quantity, corneal changes, keratitis and keratoconjunctivitis sicca . The results of the study will be posted to this site upon publication of the study.

V.  Clinical Study: Effect of Periostat on Rosacea Papules & Pustules

This clinical study is already underway. This study will determine the effect of oral Periostat on rosacea papules and pustules. These same investigators are also interested in determining the effectiveness of Periostat on ocular rosacea symptoms.

VI. Clinical Study: Effect of Topical Clonidine on Rosacea Burning Sensations and Facial Redness

This clinical study is currently going through the Human Research Committee for approval. Upon approval, the investigators will evaluate the effect of topical clonidine (0.5% - 2.0%) on burning sensations and chronic facial redness. The results of the study will be posted to this site upon publication of the study.